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Target
GTPase KRas
Ligand
BDBM50501332
Substrate
n/a
Meas. Tech.
ChEMBL_1628560 (CHEMBL3871145)
Ki
1600±n/a nM
Citation
 Xiong, Y; Lu, J; Hunter, J; Li, L; Scott, D; Choi, HG; Lim, SM; Manandhar, A; Gondi, S; Sim, T; Westover, KD; Gray, NS Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS Med Chem Lett 8:61-66 (2017) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50501332
Synonyms:
CHEMBL3982443
Type:
Small organic molecule
Emp. Form.:
C15H23ClN7O10PS
Mol. Mass.:
559.876
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)CS(=O)(=O)NCCNC(=O)CCl)[C@@H](O)[C@H]1O |r|
Structure:
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