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Target
GTPase KRas
Ligand
BDBM50501340
Substrate
n/a
Meas. Tech.
ChEMBL_1628560 (CHEMBL3871145)
Ki
>20000±n/a nM
Citation
 Xiong, Y; Lu, J; Hunter, J; Li, L; Scott, D; Choi, HG; Lim, SM; Manandhar, A; Gondi, S; Sim, T; Westover, KD; Gray, NS Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS Med Chem Lett 8:61-66 (2017) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50501340
Synonyms:
CHEMBL3936077
Type:
Small organic molecule
Emp. Form.:
C18H27N5O12P2
Mol. Mass.:
567.3808
SMILES:
COC(=O)\C=C\CCCOP(O)(=O)CP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc(N)[nH]c2=O |r|
Structure:
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