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Target
Signal peptidase I
Ligand
BDBM50501357
Substrate
n/a
Meas. Tech.
ChEMBL_1636319 (CHEMBL3879217)
IC50
48±n/a nM
Citation
 De Rosa, M; Lu, L; Zamaratski, E; Sza?aj, N; Cao, S; Wadensten, H; Lenhammar, L; Gising, J; Roos, AK; Huseby, DL; Larsson, R; Andrén, PE; Hughes, D; Brandt, P; Mowbray, SL; Karlén, A Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB). Bioorg Med Chem 25:897-911 (2017) [PubMed]  Article 
Target
Name:
Signal peptidase I
Synonyms:
LEP_ECOLI | Leader peptidase I | SPase I | lepB
Type:
PROTEIN
Mol. Mass.:
35961.43
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_154169
Residue:
324
Sequence:
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGLRLSRIGGIH
  
Inhibitor
Name:
BDBM50501357
Synonyms:
CHEMBL3957297
Type:
Small organic molecule
Emp. Form.:
C38H65BN6O9
Mol. Mass.:
760.769
SMILES:
[H][C@](NC(=O)[C@@H]1CCCN1C(=O)CCCCCCCCC)([C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)B1O[C@]2([H])C[C@]3([H])C[C@@]([H])(C3(C)C)[C@]2(C)O1 |r|
Structure:
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