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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50051998
Substrate
n/a
Meas. Tech.
ChEMBL_72475 (CHEMBL685508)
IC50
2000±n/a nM
Citation
 Schönleben-Janas, A; Kirsch, P; Mittl, PR; Schirmer, RH; Krauth-Siegel, RL Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. J Med Chem 39:1549-54 (1996) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50051998
Synonyms:
3-Methyl-10-naphthalen-1-yl-10H-benzo[g]pteridine-2,4-dione | CHEMBL287955
Type:
Small organic molecule
Emp. Form.:
C21H14N4O2
Mol. Mass.:
354.3615
SMILES:
Cn1c(=O)nc2n(-c3cccc4ccccc34)c3ccccc3nc2c1=O |(6.46,-6.99,;5.11,-6.23,;5.1,-4.68,;6.43,-3.89,;3.76,-3.92,;2.42,-4.69,;1.09,-3.95,;1.07,-2.41,;-.26,-1.65,;-.28,-.11,;1.06,.66,;2.41,-.08,;3.7,.67,;5.05,-.08,;5.05,-1.61,;3.73,-2.38,;2.41,-1.61,;-.25,-4.73,;-1.57,-3.96,;-2.91,-4.73,;-2.91,-6.27,;-1.57,-7.04,;-.25,-6.27,;1.1,-7.04,;2.44,-6.26,;3.79,-7.03,;3.8,-8.57,)|
Structure:
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