Reaction Details Report a problem with these data
Target
Polyunsaturated fatty acid lipoxygenase ALOX12
Ligand
BDBM50052474
Substrate
n/a
Meas. Tech.
ChEMBL_207 (CHEMBL615241)
IC50
30000±n/a nM
Citation
 Müller, K; Huang, HS; Wiegrebe, W Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis. J Med Chem 39:3132-8 (1996) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:
Alox12 | Alox12p | Arachidonate 12-lipoxygenase | LOX12_MOUSE
Type:
PROTEIN
Mol. Mass.:
75384.34
Organism:
Mus musculus
Description:
ChEMBL_1290357
Residue:
663
Sequence:
MGRYRVRVVTGAWLFSGSLNLVRLWLVGEHREAKLELQLRPARGKEEEFDFDVPEDLGPLQFVKLHKQHTVVDDAWFCNLITVQGPGTSAEAVFPCYRWVQGEGILSLPEGTARLAGDNALDVFQKYREKELKERQQTYCWATWKEGLPQTIAADCKDDLPPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNHLEDFDQIFWGQKSALAEKVHQCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELKNGSLFEADFILLDGIPANVIRGEPQYLAAPLVMLRMDPGGKLLPMAIQIQPPNPSSPAPTLFLPSDPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPHIRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYHSLCPPDDLANRGLLRIPSALYARDALQLWEVTARYVKGMVHLFYQSDDIVRGDPELQAWCREITEVGLCHAQDRGFPVSFQSRAQLCHFLTMCVFTCTAQHAAINQGQLDWYGWVPNAPCTMRMPPPTSKDDVTMETVMGSLPDVQKACLQMTITWHLGRLQPDMVPLGHHTEKYFSDPRTKAVLSQFQADLDNLEKEITARNEQLDLPYEYLKPSRIENSITI
  
Inhibitor
Name:
BDBM50052474
Synonyms:
(4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracen-9-ylsulfanyl)-acetic acid | CHEMBL541721
Type:
Small organic molecule
Emp. Form.:
C16H12O5S
Mol. Mass.:
316.328
SMILES:
OC(=O)CSC1c2cccc(O)c2C(=O)c2c(O)cccc12
Structure:
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