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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50503347
Substrate
n/a
Meas. Tech.
ChEMBL_1810482 (CHEMBL4309942)
IC50
0.100000±n/a nM
Citation
 Wold, EA; Chen, J; Cunningham, KA; Zhou, J Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. J Med Chem 62:88-127 (2019) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50503347
Synonyms:
CHEMBL4442431
Type:
Small organic molecule
Emp. Form.:
C11H11F3NNaO6S2
Mol. Mass.:
397.323
SMILES:
[Na;v0+].[#6]-[#6@@H](-[#6](=O)-[#7-]S([#6])(=O)=O)-c1ccc(-[#8]S(=O)(=O)C(F)(F)F)cc1 |r|
Structure:
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