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Target
Anoctamin-2
Ligand
BDBM50503452
Substrate
n/a
Meas. Tech.
ChEMBL_1810965 (CHEMBL4310425)
IC50
>100000±n/a nM
Citation
 Seo, Y; Kim, J; Chang, J; Kim, SS; Namkung, W; Kim, I Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors. Eur J Med Chem 160:245-255 (2018) [PubMed]  Article 
Target
Name:
Anoctamin-2
Synonyms:
ANO2 | ANO2_HUMAN | Anoctamin-2 | C12orf3 | TMEM16B | Transmembrane protein 16B
Type:
PROTEIN
Mol. Mass.:
113968.03
Organism:
Homo sapiens
Description:
ChEMBL_117372
Residue:
1003
Sequence:
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
  
Inhibitor
Name:
BDBM50503452
Synonyms:
CHEMBL4459865 | US11274074, Comparative Example 18 [Chemical Formula 36]
Type:
Small organic molecule
Emp. Form.:
C19H18ClF3N2O3
Mol. Mass.:
414.806
SMILES:
Cc1cc(Cl)ccc1OC(C)(C)C(=O)N\N=C\c1ccccc1OC(F)(F)F
Structure:
Search PDB for entries with ligand similarity: