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Target
Chitotriosidase-1
Ligand
BDBM50504040
Substrate
n/a
Meas. Tech.
ChEMBL_1813250 (CHEMBL4312824)
IC50
19000±n/a nM
Citation
 Mazur, M; Dymek, B; Koralewski, R; Sklepkiewicz, P; Olejniczak, S; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; J?drzejczak, K; Zagozdzon, A; Czestkowski, W; Matyszewski, K; Borek, B; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Mozga, W; Stefaniak, F; Dobrza?ski, P; Dzwonek, K; Golab, J; Golebiowski, A; Olczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem 62:7126-7145 (2019) [PubMed]  Article 
Target
Name:
Chitotriosidase-1
Synonyms:
3.2.1.14 | CHIT1_MOUSE | Chit1 | Chitinase-1 | Chitotriosidase-1
Type:
PROTEIN
Mol. Mass.:
51108.04
Organism:
Mus musculus
Description:
ChEMBL_117450
Residue:
464
Sequence:
MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDLDDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQGKADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS
  
Inhibitor
Name:
BDBM50504040
Synonyms:
CHEMBL4441922
Type:
Small organic molecule
Emp. Form.:
C18H25ClN6
Mol. Mass.:
360.884
SMILES:
Nc1n[nH]c(n1)N1CCC(CC1)N1CCCC(C1)c1ccc(Cl)cc1
Structure:
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