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Target
Bromodomain-containing protein 7
Ligand
BDBM50504159
Substrate
n/a
Meas. Tech.
ChEMBL_1813631 (CHEMBL4313205)
IC50
63096±n/a nM
Citation
 Bamborough, P; Chung, CW; Demont, EH; Bridges, AM; Craggs, PD; Dixon, DP; Francis, P; Furze, RC; Grandi, P; Jones, EJ; Karamshi, B; Locke, K; Lucas, SCC; Michon, AM; Mitchell, DJ; Pogány, P; Prinjha, RK; Rau, C; Roa, AM; Roberts, AD; Sheppard, RJ; Watson, RJ A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J Med Chem 62:7506-7525 (2019) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 7
Synonyms:
75 kDa bromodomain protein | BP75 | BRD7 | BRD7_HUMAN | CELTIX1 | Protein CELTIX-1
Type:
PROTEIN
Mol. Mass.:
74135.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107970
Residue:
651
Sequence:
MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS
  
Inhibitor
Name:
BDBM50504159
Synonyms:
CHEMBL4583297
Type:
Small organic molecule
Emp. Form.:
C20H25BrN4O5S
Mol. Mass.:
513.405
SMILES:
CC1(NC(=O)N(CC(=O)Nc2ccc(Br)c(c2)S(=O)(=O)N2CCCCC2)C1=O)C1CC1
Structure:
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