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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50054844
Substrate
n/a
Meas. Tech.
ChEMBL_208 (CHEMBL615242)
IC50
280±n/a nM
Citation
 Gorins, G; Kuhnert, L; Johnson, CR; Marnett, LJ (Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases. J Med Chem 39:4871-8 (1997) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
12-LOX | 12/15-lipoxygenase | 15-LOX | ALOX15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_PIG
Type:
PROTEIN
Mol. Mass.:
74999.86
Organism:
Sus scrofa
Description:
ChEMBL_1510008
Residue:
663
Sequence:
MGLYRVRVSTGSSFYAGSQNQVQLWLVGQHGEAALGWCLRPARGKETEFSVDVSEYLGPLLFVKLRKRHLLQDDAWFCNWISVQGPGANGDEFRFPCYRWVEGDRILSLPEGTARTVVDDPQGLFKKHREEELAERRKLYRWGNWKDGLILNIASTGIHDLPVDERFLEDKRIDFEASLAKGLADLAVKDSLNVLMSWNSLDSFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGTNPMLLRHSVELPARLKFPPGMEELQAQLEKELQGGTLFEADFSLLDGIKANVILCSQQYLAVPLVMLKLQPDGKLLPMVIQLQLPHEGSPLPPLFLPTDPPMVWLLAKCWVRSSDFQLHELHSHLLRGHLMAEVIAVATMRCLPSIHPIFKLLIPHFRYTMEINVRARNGLVSDLGIFDQVVSTGGGGHVELLRRAAALLTYSSFCPPDDLADRGLLGVESSFYAQDALRLWEVISRYVEGIVSLHYKTDESVKEDLELQAWCREFTEIGLLGAQDRGFPVSLQSKEQLCHFVTMCIFTCTGQHSSNHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRCQPTMVALGQHEEEYFSGPGPKAVLTKFREELAALDKDIEVRNAKLALPYEYLRPSRVENSVAI
  
Inhibitor
Name:
BDBM50054844
Synonyms:
3-(4-Tetradeca-2,3-dienyloxymethyl-phenyl)-propionic acid | CHEMBL344557
Type:
Small organic molecule
Emp. Form.:
C24H36O3
Mol. Mass.:
372.5408
SMILES:
CCCCCCCCCCC=C=CCOCc1ccc(CCC(O)=O)cc1 |(15.31,-23.46,;16.08,-22.13,;15.31,-20.79,;16.08,-19.44,;15.31,-18.11,;16.08,-16.78,;15.31,-15.43,;16.08,-14.1,;15.31,-12.76,;16.08,-11.42,;15.31,-10.09,;13.77,-10.09,;12.23,-10.09,;11.46,-8.76,;9.92,-8.76,;9.15,-7.43,;7.61,-7.43,;6.84,-6.1,;5.28,-6.1,;4.51,-7.43,;2.97,-7.43,;2.2,-8.76,;.66,-8.76,;-.11,-7.43,;-.11,-10.1,;5.28,-8.77,;6.84,-8.77,)|
Structure:
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