Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50055112
Substrate
n/a
Meas. Tech.
ChEMBL_195795 (CHEMBL802395)
EC50
115±n/a nM
Citation
 Johnson, AT; Klein, ES; Wang, L; Pino, ME; Chandraratna, RA Identification of retinoic acid receptor beta subtype specific agonists. J Med Chem 39:5027-30 (1997) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50055112
Synonyms:
4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthalene-2-carbonyl)-amino]-benzoic acid | CHEMBL344973
Type:
Small organic molecule
Emp. Form.:
C24H21NO3S
Mol. Mass.:
403.493
SMILES:
CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4|
Structure:
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