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Target
Cyclin-dependent kinase 2
Ligand
BDBM50504642
Substrate
n/a
Meas. Tech.
ChEMBL_1815948 (CHEMBL4315522)
IC50
1270±n/a nM
Citation
 Shawky, AM; Abourehab, MAS; Abdalla, AN; Gouda, AM Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50504642
Synonyms:
CHEMBL4592358
Type:
Small organic molecule
Emp. Form.:
C20H21BrN4O
Mol. Mass.:
413.311
SMILES:
CC(C)C\C=N\c1c(C#N)c2CCCn2c1C(=O)Nc1ccc(Br)cc1
Structure:
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