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Target
Dihydrofolate reductase
Ligand
BDBM50056236
Substrate
n/a
Meas. Tech.
ChEMBL_55124 (CHEMBL665450)
IC50
2100±n/a nM
Citation
Gangjee, A; Devraj, R; Queener, SF Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates. J Med Chem 40:470-8 (1997) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
Inhibitor
Name:
BDBM50056236
Synonyms:
6-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-[2-((E)-3,4-Dimethoxy-phenyl)-vinyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL141708
Type:
Small organic molecule
Emp. Form.:
C17H17N5O2
Mol. Mass.:
323.3492
SMILES:
COc1ccc(\C=C\c2cnc3nc(N)nc(N)c3c2)cc1OC