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Target
Neutral cholesterol ester hydrolase 1
Ligand
BDBM50052781
Substrate
n/a
Meas. Tech.
ChEMBL_1821759 (CHEMBL4321419)
IC50
>100000±n/a nM
Citation
 Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem 27:1693-1703 (2019) [PubMed]  Article 
Target
Name:
Neutral cholesterol ester hydrolase 1
Synonyms:
Aadacl1 | Arylacetamide deacetylase-like 1 | CPO-BP | Chlorpyrifos oxon-binding protein | Kiaa1363 | NCEH | NCEH1_MOUSE | Nceh1 | Neutral cholesterol ester hydrolase
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
45742.11
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant KIAA1363 transiently transfected in COS-7 cells.
Residue:
408
Sequence:
MRSSCVLLAALLALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLIALNFIITSFGKQSARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPLRRSVIYIHGGGWALASAKISYYDQLCTTMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKVDPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNTPILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNYKPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDGIMYAKRLESAGVNVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
  
Inhibitor
Name:
BDBM50052781
Synonyms:
CHEMBL3318603
Type:
Small organic molecule
Emp. Form.:
C19H20N4O
Mol. Mass.:
320.3883
SMILES:
O=C(N1CCN(Cc2ccc3ccccc3c2)CC1)n1cccn1
Structure:
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