Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50505354
Substrate
n/a
Meas. Tech.
ChEMBL_1822557 (CHEMBL4322321)
IC50
13470±n/a nM
Citation
 Wang, Z; He, N; Guo, Z; Niu, C; Song, T; Guo, Y; Cao, K; Wang, A; Zhu, J; Zhang, X; Zhang, Z Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem 62:8152-8163 (2019) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50505354
Synonyms:
CHEMBL4476628
Type:
Small organic molecule
Emp. Form.:
C51H56BrN7O9S
Mol. Mass.:
1023.001
SMILES:
Brc1ccc(Sc2ccc3C(=O)N(CCNC(=O)CCCCC(=O)NCCCCCCNC(=O)CCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)C(=O)c4cccc2c34)cc1
Structure:
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