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Target
Beta-lactamase TEM
Ligand
BDBM50505403
Substrate
n/a
Meas. Tech.
ChEMBL_1822694 (CHEMBL4322458)
IC50
3.0±n/a nM
Citation
 Krajnc, A; Brem, J; Hinchliffe, P; Calvopiņa, K; Panduwawala, TD; Lang, PA; Kamps, JJAG; Tyrrell, JM; Widlake, E; Saward, BG; Walsh, TR; Spencer, J; Schofield, CJ Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-?-Lactamases. J Med Chem 62:8544-8556 (2019) [PubMed]  Article 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50505403
Synonyms:
CHEMBL4533632
Type:
Small organic molecule
Emp. Form.:
C17H17BN2O5
Mol. Mass.:
340.138
SMILES:
NCc1ccc(cc1)C(=O)N[C@H]1Cc2cccc(C(O)=O)c2OB1O |r|
Structure:
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