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Target
NAD-dependent protein deacetylase
Ligand
BDBM27507
Substrate
n/a
Meas. Tech.
ChEMBL_1822877 (CHEMBL4322641)
IC50
420000±n/a nM
Citation
 Monaldi, D; Rotili, D; Lancelot, J; Marek, M; Wössner, N; Lucidi, A; Tomaselli, D; Ramos-Morales, E; Romier, C; Pierce, RJ; Mai, A; Jung, M Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from  J Med Chem 62:8733-8759 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase
Synonyms:
2.3.1.286 | NAD-dependent protein deacetylase | Sirt2
Type:
PROTEIN
Mol. Mass.:
38395.78
Organism:
Schistosoma mansoni
Description:
ChEMBL_119267
Residue:
337
Sequence:
MSFDFLGIKKALFGDNTPRPELKSLNIEGVAQLIQDGQVNKIITMVGAGVSTAAGIPDFRSPSSGIYDNLEDFNLPTPNAIFTIDYFRRDPRPFFEIARRLYRPEAKPTLAHCFIRLLHDKGLLLRHYTQNVDSLERLSGLPEEKLVEAHGTFHTGHCIKCNKQHDFEFMLNEILAKRVPQCLKCRNVVKPDVVLFGESMPKKFFKNLSSDLNNCDLLIIMGTSLTVLPFCAMIHRVGNDVPRLYINREYNDGSTESGLSSFIMRFMVAGFKQNYMKWGRSDNKRDIFWSGNADDGVVKISELLGWKDDLLRLKKETDSRLNEEFLAKKSQDKTNGQ
  
Inhibitor
Name:
BDBM27507
Synonyms:
3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide
Type:
n/a
Emp. Form.:
C6H6N2O
Mol. Mass.:
122.1246
SMILES:
NC(=O)c1cccnc1
Structure:
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