Reaction Details Report a problem with these data
Target
BTB/POZ domain-containing protein KCTD12
Ligand
BDBM50505521
Substrate
n/a
Meas. Tech.
ChEMBL_1822935 (CHEMBL4322699)
Ki
1340±n/a nM
Citation
 Sereikaite, V; Fritzius, T; Kasaragod, VB; Bader, N; Maric, HM; Schindelin, H; Bettler, B; Strømgaard, K Targeting the ?-Aminobutyric Acid Type B (GABA J Med Chem 62:8819-8830 (2019) [PubMed]  Article 
Target
Name:
BTB/POZ domain-containing protein KCTD12
Synonyms:
BTB/POZ domain-containing protein KCTD12 | C13orf2 | KCD12_HUMAN | KCTD12 | KIAA1778 | PFET1 | Pfetin | Predominantly fetal expressed T1 domain
Type:
PROTEIN
Mol. Mass.:
35697.33
Organism:
Homo sapiens
Description:
ChEMBL_119174
Residue:
325
Sequence:
MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYSEPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE
  
Inhibitor
Name:
BDBM50505521
Synonyms:
CHEMBL4459669
Type:
Small organic molecule
Emp. Form.:
C90H143N23O22S
Mol. Mass.:
1931.304
SMILES:
CC[C@H](C)[C@H](NC(=O)C(CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O |r|
Structure:
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