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Target
Protein-lysine 6-oxidase
Ligand
BDBM50505649
Substrate
n/a
Meas. Tech.
ChEMBL_1823506 (CHEMBL4323270)
IC50
398±n/a nM
Citation
 Findlay, AD; Foot, JS; Buson, A; Deodhar, M; Jarnicki, AG; Hansbro, PM; Liu, G; Schilter, H; Turner, CI; Zhou, W; Jarolimek, W Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. J Med Chem 62:9874-9889 (2019) [PubMed]  Article 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
1.4.3.13 | LOX | LYOX_BOVIN | Lysyl oxidase | Protein-lysine 6-oxidase | Protein-lysine 6-oxidase, long form | Protein-lysine 6-oxidase, short form
Type:
PROTEIN
Mol. Mass.:
47015.72
Organism:
Bos taurus
Description:
ChEMBL_118967
Residue:
417
Sequence:
MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLGSQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAARHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTDDNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCAAEENCLASSAYRDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM50505649
Synonyms:
CHEMBL4439437
Type:
Small organic molecule
Emp. Form.:
C18H22ClFN2O3S
Mol. Mass.:
400.895
SMILES:
Cl.C[C@H](NS(=O)(=O)c1ccc(OC\C(F)=C\CN)cc1)c1ccccc1 |r|
Structure:
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