Reaction Details
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Estrogen receptor
Ligand
BDBM263716
Substrate
n/a
Meas. Tech.
ChEMBL_1824582 (CHEMBL4324346)
EC50
0.200000±n/a nM
Citation
El-Ahmad, Y; Tabart, M; Halley, F; Certal, V; Thompson, F; Filoche-Rommé, B; Gruss-Leleu, F; Muller, C; Brollo, M; Fabien, L; Loyau, V; Bertin, L; Richepin, P; Pilorge, F; Desmazeau, P; Girardet, C; Beccari, S; Louboutin, A; Lebourg, G; Le-Roux, J; Terrier, C; Vallée, F; Steier, V; Mathieu, M; Rak, A; Abecassis, PY; Vicat, P; Benard, T; Bouaboula, M; Sun, F; Shomali, M; Hebert, A; Levit, M; Cheng, H; Courjaud, A; Ginesty, C; Perrault, C; Garcia-Echeverria, C; McCort, G; Schio, L Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3 J Med Chem 63:512-528 (2020) [PubMed] Article More Info.:
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Inhibitor
Name:
BDBM263716
Synonyms:
6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid | US9714221, Example 51
Type:
Small organic molecule
Emp. Form.:
C31H30Cl2FNO3
Mol. Mass.:
554.479
SMILES:
OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 |r,c:20|
Structure:
