Reaction Details Report a problem with these data
Target
Nicotinamide N-methyltransferase
Ligand
BDBM50506000
Substrate
n/a
Meas. Tech.
ChEMBL_1824608 (CHEMBL4324372)
Ki
1.6±n/a nM
Citation
 Chen, D; Li, L; Diaz, K; Iyamu, ID; Yadav, R; Noinaj, N; Huang, R Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide  J Med Chem 62:10783-10797 (2019) [PubMed]  Article 
Target
Name:
Nicotinamide N-methyltransferase
Synonyms:
NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT)
Type:
Protein
Mol. Mass.:
29571.16
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
264
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
  
Inhibitor
Name:
BDBM50506000
Synonyms:
CHEMBL4445337
Type:
Small organic molecule
Emp. Form.:
C24H28N8O6
Mol. Mass.:
524.5291
SMILES:
N[C@@H](CCN(CC#Cc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Structure:
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