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Target
Histone deacetylase 8
Ligand
BDBM50397360
Substrate
n/a
Meas. Tech.
ChEMBL_1826376 (CHEMBL4326250)
IC50
12±n/a nM
Citation
 Lamaa, D; Lin, HP; Zig, L; Bauvais, C; Bollot, G; Bignon, J; Levaique, H; Pamlard, O; Dubois, J; Ouaissi, M; Souce, M; Kasselouri, A; Saller, F; Borgel, D; Jayat-Vignoles, C; Al-Mouhammad, H; Feuillard, J; Benihoud, K; Alami, M; Hamze, A Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. J Med Chem 61:6574-6591 (2018) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50397360
Synonyms:
CHEMBL2170177 | US10188756, Compound CN110
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1
Structure:
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