Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50506763
Substrate
n/a
Meas. Tech.
ChEMBL_1827358 (CHEMBL4327232)
Ki
9.2±n/a nM
Citation
 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease. Eur J Med Chem 161:239-251 (2019) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50506763
Synonyms:
CHEMBL4440363
Type:
Small organic molecule
Emp. Form.:
C19H25NO3S
Mol. Mass.:
347.472
SMILES:
COC(=O)c1c(C)c(C)sc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:12:14:17.16.21:19,THB:12:14:17:21.20.19,15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14|
Structure:
Search PDB for entries with ligand similarity: