Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50508174
Substrate
n/a
Meas. Tech.
ChEMBL_1832206 (CHEMBL4332214)
IC50
0.300000±n/a nM
Citation
 Harcken, C; Kuzmich, D; Cook, B; Mao, C; Disalvo, D; Razavi, H; Swinamer, A; Liu, P; Zhang, Q; Kukulka, A; Skow, D; Patel, M; Patel, M; Fletcher, K; Sherry, T; Joseph, D; Smith, D; Canfield, M; Souza, D; Bogdanffy, M; Berg, K; Brown, M Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett 29:441-448 (2019) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50508174
Synonyms:
CHEMBL4464625
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O3S
Mol. Mass.:
453.489
SMILES:
CC[C@H](NC(=O)c1cncc2n(ncc12)-c1ccc(F)cc1)c1ccnc(c1)S(C)(=O)=O |r|
Structure:
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