Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50508210
Substrate
n/a
Meas. Tech.
ChEMBL_1832204 (CHEMBL4332212)
IC50
1.2±n/a nM
Citation
 Harcken, C; Kuzmich, D; Cook, B; Mao, C; Disalvo, D; Razavi, H; Swinamer, A; Liu, P; Zhang, Q; Kukulka, A; Skow, D; Patel, M; Patel, M; Fletcher, K; Sherry, T; Joseph, D; Smith, D; Canfield, M; Souza, D; Bogdanffy, M; Berg, K; Brown, M Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett 29:441-448 (2019) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50508210
Synonyms:
CHEMBL4518015
Type:
Small organic molecule
Emp. Form.:
C22H16F4N4O3S
Mol. Mass.:
492.446
SMILES:
CS(=O)(=O)c1cc(CNC(=O)c2cncc3n(ncc23)-c2ccc(F)cc2)cc(c1)C(F)(F)F
Structure:
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