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Target
KiSS-1 receptor
Ligand
BDBM50508231
Substrate
n/a
Meas. Tech.
ChEMBL_1832244 (CHEMBL4332252)
EC50
0.130000±n/a nM
Citation
 Nishizawa, N; Asami, T; Nishibori, K; Takatsu, Y; Suzuki, A; Ushio, K; Matsumoto, SI; Shimizu, Y; Yamaguchi, M; Kusaka, M; Matsui, H; Ohtaki, T; Kitada, C A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation. Bioorg Med Chem Lett 29:654-658 (2019) [PubMed]  Article 
Target
Name:
KiSS-1 receptor
Synonyms:
AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42613.79
Organism:
Homo sapiens (Human)
Description:
Binding assay was performed using membranes from the CHO cell transfectants.
Residue:
398
Sequence:
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
  
Inhibitor
Name:
BDBM50508231
Synonyms:
CHEMBL4459547
Type:
Small organic molecule
Emp. Form.:
C50H68N14O10
Mol. Mass.:
1025.1627
SMILES:
CNC(=N)NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)CCc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Structure:
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