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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50061915
Substrate
n/a
Meas. Tech.
ChEMBL_91742 (CHEMBL874146)
Ki
95±n/a nM
Citation
 Röver, S; Cesura, AM; Huguenin, P; Kettler, R; Szente, A Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40:4378-85 (1998) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_RAT | Kmo
Type:
PROTEIN
Mol. Mass.:
54371.88
Organism:
Rattus norvegicus
Description:
ChEMBL_1487468
Residue:
478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
  
Inhibitor
Name:
BDBM50061915
Synonyms:
2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid | CHEMBL139909 | CHEMBL554000
Type:
Small organic molecule
Emp. Form.:
C10H9Cl2NO3
Mol. Mass.:
262.089
SMILES:
NC(CC(=O)c1ccc(Cl)c(Cl)c1)C(O)=O
Structure:
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