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Target
Matrix metalloproteinase-9
Ligand
BDBM50062336
Substrate
n/a
Meas. Tech.
ChEMBL_105401 (CHEMBL710820)
Ki
0.700000±n/a nM
Citation
 Levy, DE; Lapierre, F; Liang, W; Ye, W; Lange, CW; Li, X; Grobelny, D; Casabonne, M; Tyrrell, D; Holme, K; Nadzan, A; Galardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-9
Synonyms:
67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9)
Type:
Enzyme
Mol. Mass.:
78452.28
Organism:
Homo sapiens (Human)
Description:
P14780
Residue:
707
Sequence:
MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
  
Inhibitor
Name:
BDBM50062336
Synonyms:
(R)-N*4*-Hydroxy-2-isobutyl-N*1*-((R)-1-methylcarbamoyl-2-quinolin-3-yl-ethyl)-succinamide | CHEMBL70315
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4
Mol. Mass.:
400.4714
SMILES:
CNC(=O)[C@@H](Cc1cnc2ccccc2c1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Structure:
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