Target
Neutrophil collagenase
Ligand
BDBM50062297
Substrate
n/a
Meas. Tech.
ChEMBL_105205 (CHEMBL713844)
Ki
0.33±n/a nM
Citation
 Levy, DELapierre, FLiang, WYe, WLange, CWLi, XGrobelny, DCasabonne, MTyrrell, DHolme, KNadzan, AGalardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50062297
Synonyms:
(R)-N*4*-Hydroxy-N*1*-{(R)-1-[2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-pyridin-4-yl-ethyl}-2-isobutyl-succinamide | CHEMBL302311
Type:
Small organic molecule
Emp. Form.:
C24H32N4O5
Mol. Mass.:
456.5347
SMILES:
CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](Cc1ccncc1)C(=O)NCCc1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: