Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50508999
Substrate
n/a
Meas. Tech.
ChEMBL_1837087 (CHEMBL4337220)
IC50
>10000±n/a nM
Citation
 Rodríguez-Soacha, DA; Scheiner, M; Decker, M Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. Eur J Med Chem 180:690-706 (2019) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50508999
Synonyms:
CHEMBL4445674
Type:
Small organic molecule
Emp. Form.:
C26H27ClN2O2
Mol. Mass.:
434.958
SMILES:
Clc1cccc(OC(=O)N(C2CCN(CCc3ccccc3)CC2)c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: