Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X1
Ligand
BDBM50509093
Substrate
n/a
Meas. Tech.
ChEMBL_1837351 (CHEMBL4337484)
EC50
290±n/a nM
Citation
 Prchalová, E; Hin, N; Thomas, AG; Veeravalli, V; Ng, J; Alt, J; Rais, R; Rojas, C; Li, Z; Hihara, H; Aoki, M; Yoshizawa, K; Nishioka, T; Suzuki, S; Kopajtic, T; Chatrath, S; Liu, Q; Dong, X; Slusher, BS; Tsukamoto, T Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem 62:8631-8641 (2019) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4
Type:
PROTEIN
Mol. Mass.:
36253.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_516621
Residue:
322
Sequence:
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
  
Inhibitor
Name:
BDBM50509093
Synonyms:
CHEMBL4444915
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2S
Mol. Mass.:
367.465
SMILES:
COc1cc(CNc2ccc(cc2)C(N)=N)ccc1OCc1ccsc1
Structure:
Search PDB for entries with ligand similarity: