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Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM107704
Substrate
n/a
Meas. Tech.
ChEMBL_1840411 (CHEMBL4340710)
IC50
29000±n/a nM
Citation
 Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem 27:2405-2412 (2019) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM107704
Synonyms:
US11426393, Compound Table XV.11 | US8598210, 119 | US8598210, Table XV, 10 | US8598210, Table XV, 11 | US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt | US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid | US9598370, Example 00136 | USRE47437, Example {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O4
Mol. Mass.:
306.701
SMILES:
OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Structure:
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