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Target
Dual specificity mitogen-activated protein kinase kinase 2
Ligand
BDBM50510133
Substrate
n/a
Meas. Tech.
ChEMBL_1840447 (CHEMBL4340746)
IC50
74000±n/a nM
Citation
 Ostacolo, C; Di Sarno, V; Lauro, G; Pepe, G; Musella, S; Ciaglia, T; Vestuto, V; Autore, G; Bifulco, G; Marzocco, S; Campiglia, P; Gomez-Monterrey, IM; Bertamino, A Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach. Eur J Med Chem 167:61-75 (2019) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 2
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAP2K2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK2 | MKK2 | MP2K2_HUMAN | PRKMK2 | VHL-MAP2K1/MAP2K2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44423.61
Organism:
Homo sapiens (Human)
Description:
gi_13489054
Residue:
400
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
  
Inhibitor
Name:
BDBM50510133
Synonyms:
CHEMBL4446681
Type:
Small organic molecule
Emp. Form.:
C32H30FN3O
Mol. Mass.:
491.5985
SMILES:
CN(CCc1ccc(cc1)-c1ccccc1)Cc1cn(C)c2ccc(cc12)C(=O)Nc1ccc(F)cc1
Structure:
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