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Target
Neutrophil elastase
Ligand
BDBM50064322
Substrate
n/a
Meas. Tech.
ChEMBL_63486 (CHEMBL674777)
Ki
17.9±n/a nM
KOFF
0.0000292 s-1
KON
1630 M-1s-1
Citation
 Gütschow, M; Neumann, U Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase. J Med Chem 41:1729-40 (1998) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50064322
Synonyms:
(4-Oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d][1,3]oxazin-2-ylsulfanyl)-acetic acid methyl ester | CHEMBL51649
Type:
Small organic molecule
Emp. Form.:
C13H13NO4S2
Mol. Mass.:
311.377
SMILES:
COC(=O)CSc1nc2sc3CCCCc3c2c(=O)o1
Structure:
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