Reaction Details Report a problem with these data
Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50510226
Substrate
n/a
Meas. Tech.
ChEMBL_1840933 (CHEMBL4341232)
Kd
3.0±n/a nM
Citation
 Harijan, RK; Hoff, O; Ducati, RG; Firestone, RS; Hirsch, BM; Evans, GB; Schramm, VL; Tyler, PC Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J Med Chem 62:3286-3296 (2019) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50510226
Synonyms:
CHEMBL4469129
Type:
Small organic molecule
Emp. Form.:
C18H26N8OS
Mol. Mass.:
402.517
SMILES:
Cn1cc(CCCSC[C@H]2CN(Cc3c[nH]c4c(N)ncnc34)C[C@@H]2O)nn1 |r|
Structure:
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