Reaction Details Report a problem with these data
Target
Arginase
Ligand
BDBM50510706
Substrate
n/a
Meas. Tech.
ChEMBL_1842051 (CHEMBL4342350)
IC50
16500±n/a nM
Citation
 Feitosa, LM; da Silva, ER; Hoelz, LVB; Souza, DL; Come, JAASS; Cardoso-Santos, C; Batista, MM; Soeiro, MNC; Boechat, N; Pinheiro, LCS New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors. Bioorg Med Chem 27:3061-3069 (2019) [PubMed]  Article 
Target
Name:
Arginase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
36149.67
Organism:
Leishmania amazonensis
Description:
ChEMBL_107995
Residue:
329
Sequence:
MEHVQQYKFYKEKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISDGRAIARCMMGETLLYTPHTSSKL
  
Inhibitor
Name:
BDBM50510706
Synonyms:
CHEMBL4515068
Type:
Small organic molecule
Emp. Form.:
C8H8F3N7S
Mol. Mass.:
291.256
SMILES:
Cc1cc(NNC(N)=S)n2nc(nc2n1)C(F)(F)F
Structure:
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