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Target
Cathepsin B
Ligand
BDBM50107620
Substrate
n/a
Meas. Tech.
ChEMBL_1842106 (CHEMBL4342533)
IC50
<10.0±n/a nM
Citation
 Schmitz, J; Gilberg, E; Löser, R; Bajorath, J; Bartz, U; Gütschow, M Cathepsin B: Active site mapping with peptidic substrates and inhibitors. Bioorg Med Chem 27:1-15 (2019) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50107620
Synonyms:
3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-cyano-ethoxymethyl]-benzoic acid | CHEMBL337090
Type:
Small organic molecule
Emp. Form.:
C28H27N3O5
Mol. Mass.:
485.5311
SMILES:
Cc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)N[C@@H](COCc2cccc(c2)C(O)=O)C#N)c1
Structure:
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