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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50065224
Substrate
n/a
Meas. Tech.
ChEMBL_138282 (CHEMBL744239)
IC50
216±n/a nM
Citation
 Tecle, H; Barrett, SD; Lauffer, DJ; Augelli-Szafran, C; Brann, MR; Callahan, MJ; Caprathe, BW; Davis, RE; Doyle, PD; Eubanks, D; Lipiniski, W; Mirzadegan, T; Moos, WH; Moreland, DW; Nelson, CB; Pavia, MR; Raby, C; Schwarz, RD; Spencer, CJ; Thomas, AJ; Jaen, JC Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. J Med Chem 41:2524-36 (1998) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50065224
Synonyms:
1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-methyl-but-2-enyl)-oxime | CHEMBL82378
Type:
Small organic molecule
Emp. Form.:
C11H18N2O
Mol. Mass.:
194.2734
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#8]\[#7]=[#6]-1/[#6]-[#7]-2-[#6]-[#6]-[#6]-1-[#6]-2
Structure:
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