Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50511090
Substrate
n/a
Meas. Tech.
ChEMBL_1843580 (CHEMBL4344007)
IC50
<20000±n/a nM
Citation
 Zhang, H; You, QD; Xu, XL Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective. J Med Chem 63:3785-3816 (2020) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Endoplasmic reticulum interferon stimulator | Eris | MMITA | Mediator of IRF3 activation | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein | Sting | Sting1 | Synonyms=Eris | Tmem173 | Transmembrane protein 173 | mSTING
Type:
PROTEIN
Mol. Mass.:
42834.49
Organism:
Mus musculus
Description:
ChEMBL_119061
Residue:
378
Sequence:
MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLLKNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMFGLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI
  
Inhibitor
Name:
BDBM50511090
Synonyms:
CHEMBL4454490
Type:
Small organic molecule
Emp. Form.:
C20H20ClNO4
Mol. Mass.:
373.83
SMILES:
COc1c(Cl)ccc2c1n(CC(O)=O)c1cc(ccc1c2=O)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: