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Target
Beta-glucuronidase
Ligand
BDBM50511223
Substrate
n/a
Meas. Tech.
ChEMBL_1844168 (CHEMBL4344595)
Ki
48±n/a nM
Citation
 Dashnyam, P; Lin, HY; Chen, CY; Gao, S; Yeh, LF; Hsieh, WC; Tu, Z; Lin, CH Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J Med Chem 63:4617-4627 (2020) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB
Type:
Protein
Mol. Mass.:
74467.69
Organism:
Bos taurus (Bovine)
Description:
EC 3.2.1.31, bovine liver
Residue:
652
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
  
Inhibitor
Name:
BDBM50511223
Synonyms:
CHEMBL4589187
Type:
Small organic molecule
Emp. Form.:
C6H11NO4
Mol. Mass.:
161.1558
SMILES:
O[C@@H]1CNC[C@@H]([C@H]1O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: