Reaction Details Report a problem with these data
Target
Inositol polyphosphate-5-phosphatase A
Ligand
BDBM50511346
Substrate
n/a
Meas. Tech.
ChEMBL_1844625 (CHEMBL4345052)
IC50
78000±n/a nM
Citation
 White, G; Prior, C; Mills, SJ; Baker, K; Whitfield, H; Riley, AM; Oganesyan, VS; Potter, BVL; Brearley, CA Regioisomeric Family of Novel Fluorescent Substrates for SHIP2. ACS Med Chem Lett 11:309-315 (2020) [PubMed]  Article 
Target
Name:
Inositol polyphosphate-5-phosphatase A
Synonyms:
5PTASE | I5P1_HUMAN | INPP5A | Type I inositol-1,4,5-trisphosphate 5-phosphatase
Type:
PROTEIN
Mol. Mass.:
47823.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_4316
Residue:
412
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
  
Inhibitor
Name:
BDBM50511346
Synonyms:
CHEMBL4454154
Type:
Small organic molecule
Emp. Form.:
C6H10O16P4
Mol. Mass.:
462.029
SMILES:
OP(O)(=O)Oc1cc(OP(O)(O)=O)c(OP(O)(O)=O)c(OP(O)(O)=O)c1
Structure:
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