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Target
Protein arginine N-methyltransferase 3
Ligand
BDBM50511923
Substrate
n/a
Meas. Tech.
ChEMBL_1846163 (CHEMBL4346590)
IC50
3000±n/a nM
Citation
 Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Park, KS; Chau, I; Dong, A; Zeng, H; Chen, H; Meng, F; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, J; Vedadi, M; Jin, J Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J Med Chem 63:5477-5487 (2020) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3
Synonyms:
2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Type:
PROTEIN
Mol. Mass.:
59886.87
Organism:
Homo sapiens
Description:
ChEMBL_101368
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50511923
Synonyms:
CHEMBL4463793
Type:
Small organic molecule
Emp. Form.:
C17H22N4O
Mol. Mass.:
298.3828
SMILES:
CN(CCN)Cc1c[nH]cc1-c1cccc(NC(=O)C=C)c1
Structure:
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