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Target
Urea transporter 1
Ligand
BDBM50512241
Substrate
n/a
Meas. Tech.
ChEMBL_1848172 (CHEMBL4348713)
IC50
910±n/a nM
Citation
 Zhao, Y; Li, M; Li, B; Zhang, S; Su, A; Xing, Y; Ge, Z; Li, R; Yang, B Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors. Eur J Med Chem 172:131-142 (2019) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM50512241
Synonyms:
CHEMBL4554940
Type:
Small organic molecule
Emp. Form.:
C12H12N2O3S
Mol. Mass.:
264.3
SMILES:
COC(=O)c1sc2nc(C)c(cc2c1N)C(C)=O
Structure:
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