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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM168281
Substrate
n/a
Meas. Tech.
ChEMBL_1849894 (CHEMBL4350435)
IC50
1.5±n/a nM
Citation
 Abdelaziz, AM; Basnet, SKC; Islam, S; Li, M; Tadesse, S; Albrecht, H; Gerber, C; Yu, M; Wang, S Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors. Bioorg Med Chem Lett 29:2650-2654 (2019) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM168281
Synonyms:
US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 109)
Type:
Small organic molecule
Emp. Form.:
C16H16ClN5O2
Mol. Mass.:
345.784
SMILES:
Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Structure:
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