Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50512930
Substrate
n/a
Meas. Tech.
ChEMBL_1850625 (CHEMBL4351249)
IC50
63±n/a nM
Citation
 Lemurell, M; Ulander, J; Emtenäs, H; Winiwarter, S; Broddefalk, J; Swanson, M; Hayes, MA; Prieto Garcia, L; Westin Eriksson, A; Meuller, J; Cassel, J; Saarinen, G; Yuan, ZQ; Löfberg, C; Karlsson, S; Sundqvist, M; Whatling, C Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. J Med Chem 62:4325-4349 (2019) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Human
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50512930
Synonyms:
CHEMBL4589058
Type:
Small organic molecule
Emp. Form.:
C22H29N3O4S
Mol. Mass.:
431.548
SMILES:
CC(C)(CNC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1cc[nH]n1)S(C)(=O)=O |r|
Structure:
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