Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50507336
Substrate
n/a
Meas. Tech.
ChEMBL_1851578 (CHEMBL4352202)
IC50
32±n/a nM
Citation
 Harris, PA; Faucher, N; George, N; Eidam, PM; King, BW; White, GV; Anderson, NA; Bandyopadhyay, D; Beal, AM; Beneton, V; Berger, SB; Campobasso, N; Campos, S; Capriotti, CA; Cox, JA; Daugan, A; Donche, F; Fouchet, MH; Finger, JN; Geddes, B; Gough, PJ; Grondin, P; Hoffman, BL; Hoffman, SJ; Hutchinson, SE; Jeong, JU; Jigorel, E; Lamoureux, P; Leister, LK; Lich, JD; Mahajan, MK; Meslamani, J; Mosley, JE; Nagilla, R; Nassau, PM; Ng, SL; Ouellette, MT; Pasikanti, KK; Potvain, F; Reilly, MA; Rivera, EJ; Sautet, S; Schaeffer, MC; Sehon, CA; Sun, H; Thorpe, JH; Totoritis, RD; Ward, P; Wellaway, N; Wisnoski, DD; Woolven, JM; Bertin, J; Marquis, RW Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem 62:5096-5110 (2019) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP
Type:
PROTEIN
Mol. Mass.:
74852.62
Organism:
Mus musculus
Description:
ChEMBL_116773
Residue:
656
Sequence:
MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
  
Inhibitor
Name:
BDBM50507336
Synonyms:
CHEMBL4514271
Type:
Small organic molecule
Emp. Form.:
C20H18F2N6O
Mol. Mass.:
396.3933
SMILES:
Fc1cc(F)cc(c1)[C@@H]1CC=NN1C(=O)C1CCN(CC1)c1cc(ncn1)C#N |r,c:11|
Structure:
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