Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50513270
Substrate
n/a
Meas. Tech.
ChEMBL_1852734 (CHEMBL4353358)
Ki
0.776247±n/a nM
Citation
 Franchini, S; Sorbi, C; Linciano, P; Carnevale, G; Tait, A; Ronsisvalle, S; Buccioni, M; Del Bello, F; Cilia, A; Pirona, L; Denora, N; Iacobazzi, RM; Brasili, L 1,3-Dioxane as a scaffold for potent and selective 5-HT Eur J Med Chem 176:310-325 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50513270
Synonyms:
CHEMBL4467585
Type:
Small organic molecule
Emp. Form.:
C28H31NO8
Mol. Mass.:
509.5476
SMILES:
OC(=O)C(O)=O.COc1ccccc1OCCNCC1CCOC(O1)(c1ccccc1)c1ccccc1
Structure:
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