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Target
Histone deacetylase 11
Ligand
BDBM50398716
Substrate
n/a
Meas. Tech.
ChEMBL_1854957 (CHEMBL4355686)
IC50
10600±n/a nM
Citation
 Shen, S; Hadley, M; Ustinova, K; Pavlicek, J; Knox, T; Noonepalle, S; Tavares, MT; Zimprich, CA; Zhang, G; Robers, MB; Ba?inka, C; Kozikowski, AP; Villagra, A Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem 62:8557-8577 (2019) [PubMed]  Article 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50398716
Synonyms:
CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g
Type:
Small organic molecule
Emp. Form.:
C19H23N3O3
Mol. Mass.:
341.4042
SMILES:
CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1
Structure:
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