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Target
Protein O-GlcNAcase
Ligand
BDBM50323697
Substrate
n/a
Meas. Tech.
ChEMBL_1855026 (CHEMBL4355755)
EC50
14±n/a nM
Citation
 Selnick, HG; Hess, JF; Tang, C; Liu, K; Schachter, JB; Ballard, JE; Marcus, J; Klein, DJ; Wang, X; Pearson, M; Savage, MJ; Kaul, R; Li, TS; Vocadlo, DJ; Zhou, Y; Zhu, Y; Mu, C; Wang, Y; Wei, Z; Bai, C; Duffy, JL; McEachern, EJ Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem 62:10062-10097 (2019) [PubMed]  Article 
Target
Name:
Protein O-GlcNAcase
Synonyms:
Beta-N-acetylhexosaminidase | Beta-hexosaminidase | Bifunctional protein NCOAT | Hexc | Hexc | Mea5 | Meningioma-expressed antigen 5 | Mgea5 | N-acetyl-beta-D-glucosaminidase | N-acetyl-beta-glucosaminidase | OGA_RAT | Oga | Protein O-GlcNAcase
Type:
PROTEIN
Mol. Mass.:
102878.65
Organism:
Rattus norvegicus
Description:
ChEMBL_109537
Residue:
916
Sequence:
MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
  
Inhibitor
Name:
BDBM50323697
Synonyms:
(3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL | CHEMBL1213603 | US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | US9695197, 0 | US9815861, Example 098 | thiamet-G
Type:
Small organic molecule
Emp. Form.:
C9H16N2O4S
Mol. Mass.:
248.299
SMILES:
CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3|
Structure:
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