Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50514035
Substrate
n/a
Meas. Tech.
ChEMBL_1855403 (CHEMBL4356132)
Ki
6320±n/a nM
Citation
 Yang, D; Zhang, S; Fang, X; Guo, L; Hu, N; Guo, Z; Li, X; Yang, S; He, JC; Kuang, C; Yang, Q -Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase. J Med Chem 62:9161-9174 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_HUMAN | IDO-2 | IDO2 | INDOL1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
47079.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109909
Residue:
420
Sequence:
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  
Inhibitor
Name:
BDBM50514035
Synonyms:
CHEMBL4437046
Type:
Small organic molecule
Emp. Form.:
C21H19FN4O2
Mol. Mass.:
378.3996
SMILES:
CN1CCN(Cc2ccc3nc4C(=O)c5cc(F)ccc5-n4c(=O)c3c2)CC1
Structure:
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